| The major inflammatory mediator interleukin-6 and obesity. | |
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MedLine Citation:
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PMID: 19543691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose tissue is one of the main sources of inflammatory mediators, with interleukin-6 (IL-6) among them. Although high systemic levels of inflammatory mediators are cachectogenic and/or anorexic, today it is a widely propagated thesis that in the background of obesity, a low level of chronic inflammation can be found, with IL-6 being one of the many suggested mediators. This paper reviews the studies describing elevated IL-6 levels in obese patients and the role of adipocytes and adipose-tissue macrophages in the production of IL-6. The secretion of IL-6 is regulated by several physiologic or pathologic factors: hormones, cytokines, diet, physical activity, stress, hypoxia, and others. Adipose tissue-derived IL-6 may have an effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Having a better understanding of these mechanisms may contribute to the prevention and treatment of obesity. |
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Authors:
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Katalin Eder; Noemi Baffy; Andras Falus; Andras K Fulop |
Publication Detail:
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Type: Journal Article; Review Date: 2009-06-19 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 58 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-08 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 727-36 Citation Subset: IM |
Affiliation:
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Research Group for Inflammation Biology and Immunogenomics, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary. ederkati@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism Adipose Tissue / metabolism* Anoxia / metabolism Atherosclerosis / metabolism Diet Exercise Humans Inflammation / immunology Insulin Resistance Interleukin-6* / blood, immunology Obesity / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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