Document Detail

A magnetic switch for the control of cell death signalling in in vitro and in vivo systems.
MedLine Citation:
PMID:  23042417     Owner:  NLM     Status:  MEDLINE    
The regulation of cellular activities in a controlled manner is one of the most challenging issues in fields ranging from cell biology to biomedicine. Nanoparticles have the potential of becoming useful tools for controlling cell signalling pathways in a space and time selective fashion. Here, we have developed magnetic nanoparticles that turn on apoptosis cell signalling by using a magnetic field in a remote and non-invasive manner. The magnetic switch consists of zinc-doped iron oxide magnetic nanoparticles (Zn(0.4)Fe(2.6)O(4)), conjugated with a targeting antibody for death receptor 4 (DR4) of DLD-1 colon cancer cells. The magnetic switch, in its On mode when a magnetic field is applied to aggregate magnetic nanoparticle-bound DR4s, promotes apoptosis signalling pathways. We have also demonstrated that the magnetic switch is operable at the micrometre scale and that it can be applied in an in vivo system where apoptotic morphological changes of zebrafish are successfully induced.
Mi Hyeon Cho; Eun Jung Lee; Mina Son; Jae-Hyun Lee; Dongwon Yoo; Ji-wook Kim; Seung Woo Park; Jeon-Soo Shin; Jinwoo Cheon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-07
Journal Detail:
Title:  Nature materials     Volume:  11     ISSN:  1476-1122     ISO Abbreviation:  Nat Mater     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-02-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101155473     Medline TA:  Nat Mater     Country:  England    
Other Details:
Languages:  eng     Pagination:  1038-43     Citation Subset:  IM    
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
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MeSH Terms
Apoptosis / physiology*
Cell Death / physiology
Cells, Cultured
Magnetite Nanoparticles*
Signal Transduction*
Reg. No./Substance:
0/Magnetite Nanoparticles
Comment In:
Nat Mater. 2012 Dec;11(12):1006-8   [PMID:  23175046 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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