Document Detail

A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls.
MedLine Citation:
PMID:  10641579     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to compare thalamic size in adolescent patients with either schizophrenia or bipolar disorder and healthy controls. T2-weighted axial magnetic resonance images were used to manually define the area of the thalamus for 20 schizophrenia patients, 15 bipolar patients and 16 normal control subjects, all of whom were adolescents. Two orthogonal planned contrasts were tested: Contrast 1, patients with schizophrenia vs. patients with bipolar disorder; and Contrast 2, both patient groups taken as a single group compared to controls. Contrast 1 was not statistically significant for right or left thalamic area. Contrast 2 was statistically significant and indicated reductions in thalamic area in the patients as compared to controls. The same pattern of results emerged after adjustment for total brain volume. Our results indicate that thalamic abnormalities reported in adult schizophrenic and bipolar patients are also observed in adolescent patients. Our findings also add to the evidence implicating the thalamus in the pathophysiology of schizophrenia and bipolar disorder.
M Dasari; L Friedman; J Jesberger; T A Stuve; R L Findling; T P Swales; S C Schulz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  91     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
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MeSH Terms
Bipolar Disorder / diagnosis*,  physiopathology
Dominance, Cerebral / physiology
Magnetic Resonance Imaging*
Reference Values
Schizophrenia / diagnosis*,  physiopathology
Thalamus / pathology*,  physiopathology

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