Document Detail


A magnetic resonance imaging study of schizophrenia: brain structure and clinical symptoms.
MedLine Citation:
PMID:  2012905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-one patients with schizophrenia and 33 normal control subjects underwent MRI. The BPRS was used to rate clinical symptoms and the NART to estimate pre-morbid IQ. All were right handed. The temporal lobe was significantly smaller on the left than the right in both the control and schizophrenic groups. The amygdala was smaller on the left than the right in controls but not in schizophrenics. The parahippocampal gyrus was smaller on the left side in the schizophrenic group but not in controls. In the schizophrenic group, ventricular enlargement and cerebral atrophy were significantly related to severity of symptoms. Patients with marked negative symptoms had a bilateral reduction in the size of the head of caudate and the two measures were significantly correlated. Patients with marked positive symptoms had larger VBRs and again the clinical and morphometric changes were significantly correlated. There were no morphometric differences between patients with short duration (two years or less) and chronic symptoms.
Authors:
A H Young; D H Blackwood; H Roxborough; J K McQueen; M J Martin; D Kean
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  158     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-13     Completed Date:  1991-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atrophy / pathology
Brain / pathology*
Cerebral Ventricles / pathology
Chronic Disease
Female
Humans
Intelligence Tests
Limbic System / pathology
Magnetic Resonance Imaging*
Male
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / diagnosis*
Schizophrenic Psychology
Temporal Lobe / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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