Document Detail

A magnetic resonance imaging study of putamen nuclei in major depression.
MedLine Citation:
PMID:  1763144     Owner:  NLM     Status:  MEDLINE    
The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depressive mood, and psychosis. Using high resolution, axial T2 intermediate magnetic resonance images, and a systematic sampling stereologic method, we assessed putamen nuclei volumes in 41 patients with major depression (DSM-III) and 44 healthy volunteer controls of similar age. Depressed patients had significantly smaller putamen nuclei compared with controls. Age was negatively correlated with putamen size in both groups. These results are the first demonstration of diminished putamen volumes in depression and further support a role for basal ganglia structures in the etiopathogenesis of depression.
M M Husain; W M McDonald; P M Doraiswamy; G S Figiel; C Na; P R Escalona; O B Boyko; C B Nemeroff; K R Krishnan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  40     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-10     Completed Date:  1992-02-10     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Basal Ganglia Diseases / diagnosis*,  pathology,  psychology
Brain Damage, Chronic / diagnosis,  pathology,  psychology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis*,  pathology,  psychology
Depressive Disorder / diagnosis*,  pathology,  psychology
Limbic System / pathology
Magnetic Resonance Imaging*
Middle Aged
Putamen / pathology*
Grant Support

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