| Fe(3)O(4)/TiO(2) core/shell magnetic nanoparticle-based photokilling of pathogenic bacteria. | |
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MedLine Citation:
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PMID: 21143035 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: We demonstrate a photokilling approach for pathogenic bacteria using magnetic nanoparticles as photokilling nanoprobes. Materials & methods: The nanoprobes are composed of iron oxide/titania (Fe(3)O(4)/TiO(2)) core/shell magnetic nanoparticles. The titanium layer on the magnetic nanoprobes plays two roles: as a photokilling agent and as an affinity substrate for pathogenic bacteria. The magnetic property of the nanoprobes allows the resultant nanoprobe-target species conjugates to be readily aggregated at a small spot under external magnetic field for conducting photokilling treatment. Therefore, damage to nontarget cells can be reduced. Results: The results show that Fe(3)O(4)/TiO(2) core/shell magnetic nanoparticles do not only have the capacity to target pathogenic bacteria, including Gram-negative, Gram-positive and antibiotic-resistant bacteria, but they can also be used to effectively inhibit the cell growth of the bacteria (>99.9%) targeted by the magnetic nanoparticles under irradiation of a low-power UV lamp (λ(max) ∼306 nm, 0.412 mW/cm(2)) within 15 min. Conclusion: The potential application of this approach is in the treatment of cutaneous bacterial infections. |
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Authors:
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Wei-Jen Chen; Yu-Chie Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: 5 ISSN: 1748-6963 ISO Abbreviation: Nanomedicine (Lond) Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1585-93 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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