Document Detail

The magic and mystery of miR-21.
MedLine Citation:
PMID:  20978356     Owner:  NLM     Status:  MEDLINE    
MicroRNAs (miRNAs) are potent regulators of mRNA stability and thereby protein expression. As such, miRNAs have become of interest as possible therapeutics and/or therapeutic targets. In this context, small complementary miRNA sequences known as antagomirs could be used to inhibit miRNA activity, while miRNA mimics could confer gain-of-function activity. However, a note of caution is sounded by Patrick et al. in this issue of the JCI, as they show that although recent reports have suggested that an miR-21 antagomir might be therapeutically useful in preventing heart failure in mice, genetic deletion of miR-21 does not confer a similar phenotype, suggesting possible confounding factors that are only now beginning to be revealed in the techniques used to study miRNA biology.
Edward E Morrisey
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-18
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2010-12-07     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3817-9     Citation Subset:  AIM; IM    
Department of Medicine, Institute for Regenerative Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Base Sequence
Heart Failure / genetics,  prevention & control
MicroRNAs / chemistry,  genetics*,  metabolism*
Models, Genetic
Molecular Sequence Data
Nucleic Acid Conformation
RNA Stability
Grant Support
Reg. No./Substance:
Comment On:
J Clin Invest. 2010 Nov;120(11):3912-6   [PMID:  20978354 ]

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