Document Detail


Waldenström's macroglobulinemia associated with AA amyloidosis.
MedLine Citation:
PMID:  11530809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is widely accepted that amyloidosis in Waldenström's macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM. We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients.
Authors:
J Gardyn; A Schwartz; R Gal; U Lewinski; D Kristt; A M Cohen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of hematology     Volume:  74     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-09-03     Completed Date:  2001-12-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  76-8     Citation Subset:  IM    
Affiliation:
Hematology Unit, Rabin Medical Center, Petah-Tikva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amyloidosis / etiology*,  metabolism
Coloring Agents
Congo Red
Fatal Outcome
Humans
Male
Potassium Permanganate
Serum Amyloid A Protein / analysis*
Waldenstrom Macroglobulinemia / complications*
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Serum Amyloid A Protein; 573-58-0/Congo Red; 7722-64-7/Potassium Permanganate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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