| A machine-learning approach to the prediction of oxidative stress in chronic inflammatory disease. | |
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MedLine Citation:
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PMID: 19161675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress is implicated in the development of a wide range of chronic human diseases, ranging from cardiovascular to neurodegenerative and inflammatory disorders. As oxidative stress results from a complex cascade of biochemical reactions, its quantitative prediction remains incomplete. Here, we describe a machine-learning approach to the prediction of levels of oxidative stress in human subjects. From a database of biochemical analyses of oxidative stress biomarkers in blood, plasma and urine, non-linear models have been designed, with a statistical methodology that includes variable selection, model training and model selection. Our data demonstrate that, despite a large inter- and intra-individual variability, levels of biomarkers of oxidative damage in biological fluids can be predicted quantitatively from measured concentrations of a limited number of exogenous and endogenous antioxidants. |
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Authors:
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A Magon de la Villehuchet; M Brack; G Dreyfus; Y Oussar; D Bonnefont-Rousselot; M J Chapman; A Kontush |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 14 ISSN: 1743-2928 ISO Abbreviation: Redox Rep. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
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Languages: eng Pagination: 23-33 Citation Subset: IM |
Affiliation:
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Ecole Supérieure de Physique et de Chimie Industrielles, ESPCI-Paristech, Laboratoire d'Electronique (CNRS UMR 7084), Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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analysis* Artificial Intelligence* Biological Markers / blood* Cardiovascular Diseases / blood, pathology Chronic Disease Female Humans Inflammation / blood, pathology Male Models, Biological Neurodegenerative Diseases / blood, pathology Oxidative Stress* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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