| mTOR signaling: RAG GTPases transmit the amino acid signal. | |
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MedLine Citation:
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PMID: 18929489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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mTOR (mammalian target of rapamycin) is a highly conserved nutrient-responsive regulator of cell growth that is found in all eukaryotes. The mechanism by which amino acids signal to mTOR has remained one of the largest outstanding questions in the field. Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR. |
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Authors:
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Reuben J Shaw |
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Publication Detail:
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Type: Journal Article Date: 2008-10-15 |
Journal Detail:
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Title: Trends in biochemical sciences Volume: 33 ISSN: 0968-0004 ISO Abbreviation: Trends Biochem. Sci. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-01-26 Revised Date: 2011-05-12 |
Medline Journal Info:
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Nlm Unique ID: 7610674 Medline TA: Trends Biochem Sci Country: England |
Other Details:
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Languages: eng Pagination: 565-8 Citation Subset: IM |
Affiliation:
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Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. shaw@salk.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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physiology* Animals Guanine Nucleotide Exchange Factors / metabolism Guanosine Triphosphate / metabolism Humans Monomeric GTP-Binding Proteins / metabolism, physiology* Neuropeptides / metabolism Protein Kinases / physiology* Signal Transduction / physiology* TOR Serine-Threonine Kinases |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA120964-01A1/CA/NCI NIH HHS; R01 DK080425-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Guanine Nucleotide Exchange Factors; 0/Neuropeptides; 0/RHEB protein, human; 86-01-1/Guanosine Triphosphate; EC 2.7.-/Protein Kinases; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 3.6.5.2/Monomeric GTP-Binding Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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