Document Detail


mTOR, metabolism, and the regulation of T-cell differentiation and function.
MedLine Citation:
PMID:  22889214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy requirements for this expansion are formidable, and T-cell activation is accompanied by dramatic changes in cellular metabolism. Furthermore, the outcome of antigen engagement is guided by multiple cues derived from the immune microenvironment. Mammalian target of rapamycin (mTOR) is emerging as a central integrator of these signals playing a critical role in driving T-cell differentiation and function. Indeed, multiple metabolic programs are controlled by mTOR signaling. In this review, we discuss the role of mTOR in regulating metabolism and how these pathways intersect with the ability of mTOR to integrate cues that guide the outcome of T-cell receptor engagement.
Authors:
Adam T Waickman; Jonathan D Powell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  249     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2013-02-04     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  43-58     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Energy Metabolism*
Humans
Lymphocyte Activation*
Pentose Phosphate Pathway
Receptors, Antigen, T-Cell / immunology,  metabolism
Signal Transduction
T-Lymphocytes / cytology,  immunology*,  metabolism*
TOR Serine-Threonine Kinases / metabolism*
Grant Support
ID/Acronym/Agency:
R01 AI077610/AI/NIAID NIH HHS; R01 AI091481/AI/NIAID NIH HHS; R01 AI091481-01/AI/NIAID NIH HHS; R01AI077610/AI/NIAID NIH HHS; T32 AI007247/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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