Document Detail


mTOR is a key modulator of ageing and age-related disease.
MedLine Citation:
PMID:  23325216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of 'when' rather than 'if'. A leading target for such interventions is the nutrient response pathway defined by the mechanistic target of rapamycin (mTOR). Inhibition of this pathway extends lifespan in model organisms and confers protection against a growing list of age-related pathologies. Characterized inhibitors of this pathway are already clinically approved, and others are under development. Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans.
Authors:
Simon C Johnson; Peter S Rabinovitch; Matt Kaeberlein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature     Volume:  493     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-04     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*,  pathology
Animals
Humans
Insulin / metabolism
Insulin-Like Growth Factor I / metabolism
Longevity / genetics
Signal Transduction
TOR Serine-Threonine Kinases / metabolism*
Grant Support
ID/Acronym/Agency:
P30 AG013280/AG/NIA NIH HHS; R01 AG031108/AG/NIA NIH HHS; R01 AG038550/AG/NIA NIH HHS; R01 AG039390/AG/NIA NIH HHS; R01AG031108/AG/NIA NIH HHS; R01AG039390/AG/NIA NIH HHS; T32 AG000057/AG/NIA NIH HHS; T32AG000057/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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