| mTOR inhibitor-associated dermatologic and mucosal problems. | |
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MedLine Citation:
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PMID: 20236129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammalian target of rapamycin inhibitor use is associated with numerous adverse events, including dermatologic and mucosal problems. Awareness of these complications, which clinically manifest across a severity spectrum from minor through severe and may occur at varied time points after initiation of sirolimus therapy, can be useful to clinicians in both managing these events and determining the appropriate intervention(s) for patients. This manuscript examines the dermatologic and mucosal problems associated with mammalian target of rapamycin inhibitor use, reviews the literature, and provides personal experiences regarding the management and treatment of these adverse events. |
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Authors:
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Josep M Campistol; Johan W de Fijter; Stuart M Flechner; Anthony Langone; Emmanuel Morelon; Eggert Stockfleth |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-04 |
Journal Detail:
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Title: Clinical transplantation Volume: 24 ISSN: 1399-0012 ISO Abbreviation: Clin Transplant Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-24 Revised Date: 2010-11-10 |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 149-56 Citation Subset: IM |
Affiliation:
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Department of Urology and Nephrology, Hospital Clinic i Provincial, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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chemically induced Algorithms Calcineurin / antagonists & inhibitors Exanthema / therapy Folliculitis / chemically induced Humans Immunosuppressive Agents / adverse effects* Intracellular Signaling Peptides and Proteins / antagonists & inhibitors* Kidney Transplantation Nail Diseases / chemically induced Protein-Serine-Threonine Kinases / antagonists & inhibitors* Pruritus / therapy Sirolimus / adverse effects* Skin / drug effects* Stomatitis, Aphthous / chemically induced, immunology Vasculitis / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Intracellular Signaling Peptides and Proteins; 53123-88-9/Sirolimus; EC 2.7.1.-/mTOR protein; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.1.3.16/Calcineurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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