Document Detail


mTOR--beyond transplantation.
MedLine Citation:
PMID:  15955739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
mTOR kinase plays a central role in the activation of many cell types, and blocking mTOR function with rapamycin results in arrest of the cell cycle at the G1 phase. Recently, several additional molecules have been identified in the mTOR pathway, providing further opportunities to interfere with cell activation and develop novel therapeutic agents. Under certain conditions and in specific cell types, activation can occur independently of mTOR and in the presence of rapamycin. Selective inhibition of cell activation in the appropriate setting might prove to be beneficial for several autoimmune or inflammatory diseases.
Authors:
Deborah A Young; Cheryl L Nickerson-Nutter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  5     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-06     Completed Date:  2006-05-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  IM    
Affiliation:
Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA. dyoung@wyeth.com
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / drug therapy,  immunology,  physiopathology
Dendritic Cells / immunology,  physiology
Humans
Inflammation / drug therapy,  immunology,  physiopathology
Protein Kinases / physiology*
Signal Transduction / drug effects*,  physiology
Chemical
Reg. No./Substance:
EC 2.7.-/Protein Kinases; EC 2.7.1.-/mTOR protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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