| mTOR and Akt signaling in cancer: SGK cycles in. | |
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MedLine Citation:
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PMID: 18614042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a recent issue of Molecular Cell, Hong et al. (2008) describe an alternative mechanism by which mTOR promotes cell-cycle progression; it phosphorylates and activates SGK, which in turn phosphorylates the cell-cycle inhibitor p27, promoting its cytoplasmic retention. |
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Authors:
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Alex Toker |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Molecular cell Volume: 31 ISSN: 1097-4164 ISO Abbreviation: Mol. Cell Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-10 Completed Date: 2008-08-04 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9802571 Medline TA: Mol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 6-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. atoker@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Cyclin-Dependent Kinase Inhibitor p27 / metabolism Enzyme Activation Humans Immediate-Early Proteins / metabolism* Neoplasms / enzymology* Phosphatidylinositol 3-Kinases / metabolism Phosphorylation Protein Kinases / metabolism* Protein-Serine-Threonine Kinases / metabolism* Proto-Oncogene Proteins c-akt / metabolism* Signal Transduction* TOR Serine-Threonine Kinases |
| Chemical | |
Reg. No./Substance:
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0/Immediate-Early Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 2.7.-/Protein Kinases; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/serum-glucocorticoid regulated kinase |
| Comments/Corrections | |
Comment On:
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Mol Cell. 2008 Jun 20;30(6):701-11
[PMID:
18570873
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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