Document Detail

mRNA of placental origin in maternal serum of women with normal and preeclamptic pregnancies.
MedLine Citation:
PMID:  19521094     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We quantified placenta-specific mRNA from maternal blood to evaluate differences in normal and preeclamptic pregnancies. METHODS: mRNA was purified from 560 microl serum using the QIAamp Viral RNA Mini Kit in 8 women with normal and 8 women with preeclamptic pregnancies. RESULTS: The relative amounts for beta-hCG, CRH and hPL in serum samples of each study group showed a broad variety in the expression levels within one group. Higher amounts for CRH were found in most cases of preeclampsia, for beta-hCG and hPL the amounts for women with preeclamptic pregnancies were tenfold below the values found for normal pregnancies. CONCLUSION: This method is not useful to distinguish between normal and preeclamptic pregnancies in the second trimester and later. Whether it can be applied for early diagnosis of preeclampsia has to be elucidated in further studies.
Markus Schmidt; Barbara Hoffmann; Rainer Kimmig; Sabine Kasimir-Bauer
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Publication Detail:
Type:  Journal Article     Date:  2009-06-11
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 S. Karger AG, Basel.
Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood,  genetics
Corticotropin-Releasing Hormone / blood,  genetics
In Situ Hybridization, Fluorescence
Maternal-Fetal Exchange*
Placenta / cytology*
Placental Lactogen / blood,  genetics
Polymerase Chain Reaction
Pre-Eclampsia / blood*,  genetics
RNA, Messenger / blood*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/RNA, Messenger; 9015-71-8/Corticotropin-Releasing Hormone; 9035-54-5/Placental Lactogen

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