| mRNA microarray analysis in lymphoma and leukemia. | |
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MedLine Citation:
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PMID: 15217204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have reviewed the ability of gene expression microarrays to characterize subgroups of lymphoma and leukemia, identify expression profiles that correlate with known cytogenetic abnormalities, demonstrate that expression profiles can predict prognosis, new proteins identified for diagnosis and followup, and provided new therapeutic targets for chemotherapy. We can expect that new prognostic models will be designed and tested, incorporating the pathologic diagnosis based on morphology, the molecular gene expression profile, and the clinical assessment (e.g. International prognostic index). In addition, the gene expression profiles will be used to generate correlative and ultimately predictive data for response to particular chemotherapeutic regimens. Translation for clinical usage is likely in a diagnostic fashion in both lymphoma and leukemia. |
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Authors:
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Timothy C Greiner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cancer treatment and research Volume: 121 ISSN: 0927-3042 ISO Abbreviation: Cancer Treat. Res. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-06-25 Completed Date: 2004-07-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8008541 Medline TA: Cancer Treat Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans Leukemia / genetics* Lymphoma / genetics* Oligonucleotide Array Sequence Analysis* RNA, Messenger / analysis* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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