Document Detail

mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin.
MedLine Citation:
PMID:  18997394     Owner:  NLM     Status:  MEDLINE    
Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.
Yurika Mizobe; Daichi Oikawa; Shoichiro Tsuyama; Yoriko Akimoto; Kousuke Hamasu; Eiichiro Onitsuka; Mikako Sato; Yoshihisa Takahata; Fumiki Morimatsu; Mitsuhiro Furuse
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Publication Detail:
Type:  Journal Article     Date:  2008-11-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  72     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  3067-70     Citation Subset:  IM    
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuaka-shi, Japan.
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MeSH Terms
Circadian Rhythm / genetics
Gene Expression Regulation, Enzymologic*
Matrix Metalloproteinase 12 / genetics*
Protein-Lysine 6-Oxidase / genetics*
RNA, Messenger / genetics,  metabolism
Sex Characteristics
Skin / metabolism*
Reg. No./Substance:
0/RNA, Messenger; EC 6-Oxidase; EC Metalloproteinase 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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