| mGluR2 postsynaptically senses granule cell inputs at Golgi cell synapses. | |
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MedLine Citation:
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PMID: 12948448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the cerebellar circuit, Golgi cells are thought to contribute to information processing and integration via feedback mechanisms. In these mechanisms, dynamic modulation of Golgi cell excitability is necessary because GABA from Golgi cells causes tonic inhibition on granule cells. We studied the role and synaptic mechanisms of postsynaptic metabotropic glutamate receptor subtype 2 (mGluR2) at granule cell-Golgi cell synapses, using whole-cell recording of green fluorescent protein-positive Golgi cells of wild-type and mGluR2-deficient mice. Postsynaptic mGluR2 was activated by glutamate from granule cells and hyperpolarized Golgi cells via G protein-coupled inwardly rectifying K+ channels (GIRKs). This hyperpolarization conferred long-lasting silencing of Golgi cells, the duration and extents of which were dependent on stimulus strengths. Postsynaptic mGluR2 thus senses inputs from granule cells and is most likely important for spatiotemporal modulation of mossy fiber-granule cell transmission before distributing inputs to Purkinje cells. |
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Authors:
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Dai Watanabe; Shigetada Nakanishi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 39 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2003-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 821-9 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebellum / cytology, physiology Electric Stimulation Excitatory Postsynaptic Potentials / physiology G Protein-Coupled Inwardly-Rectifying Potassium Channels Glutamic Acid / metabolism Green Fluorescent Proteins Humans Immunohistochemistry Luminescent Proteins Mice Mice, Knockout Mice, Transgenic Neurons / physiology* Patch-Clamp Techniques Potassium Channels / metabolism Potassium Channels, Inwardly Rectifying* Receptors, AMPA / metabolism Receptors, Metabotropic Glutamate / deficiency, physiology* Synapses / physiology* |
| Chemical | |
Reg. No./Substance:
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0/G Protein-Coupled Inwardly-Rectifying Potassium Channels; 0/Luminescent Proteins; 0/Potassium Channels; 0/Potassium Channels, Inwardly Rectifying; 0/Receptors, AMPA; 0/Receptors, Metabotropic Glutamate; 0/metabotropic glutamate receptor 2; 147336-22-9/Green Fluorescent Proteins; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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