Document Detail

mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.
MedLine Citation:
PMID:  12151028     Owner:  NLM     Status:  MEDLINE    
The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been shown to modify central serotonergic parameters relevant to ingestive behavior. Evidence suggests an association between the 5-HT(2C) receptor and fat intake. The present research sought to examine the role of the 5-HT(2C) receptor subtype on food intake when diets with different fatty acid compositions are consumed. The effects of 1-(3-chlorophenyl)piperazine (mCPP) on consumption of both low-fat (Experiment 1) and high-fat diets (Experiment 2) differing in their predominant PUFA profiles were compared in rats. Regardless of the PUFA profile, mCPP induced hypophagia within each experiment. Although the present results lend further support to a large body of evidence demonstrating the ability of mCPP to reduce food intake, they do not support the idea that the essential fatty acid composition of the diet can differentially modulate mCPP-induced hypophagia.
H B Rice; R L Corwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  73     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2003-02-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Nutrition Department/Graduate Program in Nutrition, College of Health and Human Development, The Pennsylvania State University, 126 Henderson Building South, University Park 16802, USA.
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MeSH Terms
Body Weight / drug effects
Dietary Fats / pharmacology
Dose-Response Relationship, Drug
Energy Intake / drug effects
Fatty Acids, Omega-3 / pharmacology
Fatty Acids, Unsaturated / pharmacology*
Feeding Behavior / drug effects*
Piperazines / pharmacology*
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin / drug effects
Serotonin Agonists / pharmacology*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Piperazines; 0/Receptor, Serotonin, 5-HT2C; 0/Receptors, Serotonin; 0/Serotonin Agonists; 6640-24-0/1-(3-chlorophenyl)piperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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