Document Detail


mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.
MedLine Citation:
PMID:  12151028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been shown to modify central serotonergic parameters relevant to ingestive behavior. Evidence suggests an association between the 5-HT(2C) receptor and fat intake. The present research sought to examine the role of the 5-HT(2C) receptor subtype on food intake when diets with different fatty acid compositions are consumed. The effects of 1-(3-chlorophenyl)piperazine (mCPP) on consumption of both low-fat (Experiment 1) and high-fat diets (Experiment 2) differing in their predominant PUFA profiles were compared in rats. Regardless of the PUFA profile, mCPP induced hypophagia within each experiment. Although the present results lend further support to a large body of evidence demonstrating the ability of mCPP to reduce food intake, they do not support the idea that the essential fatty acid composition of the diet can differentially modulate mCPP-induced hypophagia.
Authors:
H B Rice; R L Corwin
Related Documents :
12884098 - Beneficial effects of n-9 eicosatrienoic acid on experimental bowel lesions.
19437028 - A dietary combination of omega-3 and omega-6 polyunsaturated fatty acids is more effici...
10858408 - Effects of eicosapentaenoic and gamma-linolenic acids (dietary lipids) on pulmonary sur...
12680858 - Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord bl...
1499538 - Milk and water intakes of foals sucking grazing mares.
17634578 - Methods for nutrigenomics and longevity studies in drosophila: effects of diets high in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  73     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2003-02-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Affiliation:
Nutrition Department/Graduate Program in Nutrition, College of Health and Human Development, The Pennsylvania State University, 126 Henderson Building South, University Park 16802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Diet*
Dietary Fats / pharmacology
Dose-Response Relationship, Drug
Energy Intake / drug effects
Fatty Acids, Omega-3 / pharmacology
Fatty Acids, Unsaturated / pharmacology*
Feeding Behavior / drug effects*
Male
Piperazines / pharmacology*
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin / drug effects
Serotonin Agonists / pharmacology*
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Piperazines; 0/Receptor, Serotonin, 5-HT2C; 0/Receptors, Serotonin; 0/Serotonin Agonists; 6640-24-0/1-(3-chlorophenyl)piperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Behavioral responses to stress following central and peripheral injection of the 5-HT(2) agonist DOI...
Next Document:  Investigation of a possible sensitization development to a challenge dose of ethanol after 2 weeks f...