| mCD24 regulates proliferation of neuronal committed precursors in the subventricular zone. | |
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MedLine Citation:
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PMID: 15737737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously showed that deletion of the cell surface molecule mCD24 resulted in an increased proliferation in adult subventricular zone (SVZ). Here, we report an increased PSA-NCAM+/TuJ1- population in the mCD24-/- in vivo SVZ as well as in vitro neurospheres. Isolated in vitro, these cells were able to generate neurospheres. Proliferation studies, using BrdU incorporation, showed an increased proliferation in P7 mCD24-/- SVZ and neurospheres. Using electron microscopy, the same cell types were identified in the in vivo SVZ as well as in vitro neurospheres from the WT and mCD24-/- mice. In mixed neurospheres, formed with WT and EGFP/KO cells (enhanced green fluorescent protein mCD24-/-), the WT environment was able to control the proliferation rate of the mCD24-/- cells, but was unable to regulate their differentiation. We concluded that mCD24 acts cell nonautonomously to regulate transit-amplifying cells proliferation and/or differentiation. |
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Authors:
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Vincent Nieoullon; Richard Belvindrah; Geneviève Rougon; Geneviève Chazal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 28 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-01 Completed Date: 2005-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 462-74 Citation Subset: IM |
Affiliation:
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Neurogenèse et Morphogenèse dans le Développement et chez l'Adulte/Institut de Biologie du Développement de Marseille, Centre National de la Recherche Scientifique, Marseilles, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Antigens, CD / genetics, metabolism, physiology* Antigens, CD24 Cell Differentiation / physiology* Cell Lineage / physiology Cell Proliferation* Cells, Cultured Green Fluorescent Proteins Lateral Ventricles / growth & development*, metabolism*, ultrastructure Male Membrane Glycoproteins / genetics, metabolism, physiology* Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron, Transmission Neural Cell Adhesion Molecule L1 / metabolism Neurons / metabolism, ultrastructure P-Selectin / metabolism Sialic Acids / metabolism Stem Cells / metabolism*, ultrastructure Tubulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD24; 0/Cd24a protein, mouse; 0/Membrane Glycoproteins; 0/Neural Cell Adhesion Molecule L1; 0/P-Selectin; 0/Sialic Acids; 0/Tubulin; 0/beta3 tubulin, mouse; 0/polysialyl neural cell adhesion molecule; 147336-22-9/Green Fluorescent Proteins |
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