Document Detail


mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells.
MedLine Citation:
PMID:  18359297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
mAtNOS1 is a novel gene recently reported in mammalian cells with functions that are not fully understood. The present study generated human neuroblastoma SHSY cells over- and underexpressing mAtNOS1 and shows that mAtNOS1 is involved in regulating mitochondrial nitric oxide, mitochondrial transmembrane potential, protein tyrosine nitration, cytochrome c release, and apoptosis of those cells.
Authors:
Mordhwaj S Parihar; Arti Parihar; Zhonghai Chen; Rafal Nazarewicz; Pedram Ghafourifar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1780     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  921-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis* / genetics
Apoptosis Regulatory Proteins / genetics,  metabolism*
Arabidopsis / genetics,  metabolism
Arabidopsis Proteins / genetics,  metabolism
Brain / embryology,  metabolism
COS Cells
Cell Line, Tumor
Cercopithecus aethiops
Embryo, Mammalian / embryology,  metabolism
GTP-Binding Proteins / genetics,  metabolism*
Humans
Membrane Potentials / genetics
Mice
Mitochondria / genetics,  metabolism*
Mitochondrial Membranes / metabolism
Mutation
Neoplasm Proteins / genetics,  metabolism*
Neuroblastoma / genetics,  metabolism*
Nitric Oxide / metabolism*
Nitric Oxide Synthase / genetics,  metabolism
Sequence Homology, Amino Acid
Thymus Gland / embryology,  metabolism
Grant Support
ID/Acronym/Agency:
AG023264-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Arabidopsis Proteins; 0/Neoplasm Proteins; 10102-43-9/Nitric Oxide; EC 1.14.13.39/NOA1 protein, Arabidopsis; EC 1.14.13.39/Nitric Oxide Synthase; EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.1.-/mAtNOS1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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