| m-Hydroxyphenylacetic acid formation from L-dopa in man: suppression by neomycin. | |
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MedLine Citation:
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PMID: 5350345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increased excretion of m-hydroxyphenylacetic acid in the urine of patients with parkinsonism being treated with L-dopa was reduced by gut sterilization with neomycin. The p-de-hydroxylation step is thus brought about solely by the action of gut flora; the pathway is unlikely to be involved in the events within the brain leading to the therapeutic benefit effected by L-dopa. |
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Authors:
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M Sandler; F Karoum; C R Ruthven; D B Calne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 166 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1969 Dec |
Date Detail:
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Created Date: 1969-12-30 Completed Date: 1969-12-30 Revised Date: 2011-07-18 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1417-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dihydroxyphenylalanine
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metabolism* Humans Intestines / microbiology Neomycin / administration & dosage* Parkinson Disease / drug therapy, metabolism*, urine Phenylacetates / urine* |
| Chemical | |
Reg. No./Substance:
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0/Phenylacetates; 1404-04-2/Neomycin; 63-84-3/Dihydroxyphenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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