| m-Chlorophenylpiperazine decreases food intake in a test meal. | |
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MedLine Citation:
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PMID: 7862925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects. |
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Authors:
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A E Walsh; K A Smith; A D Oldman; C Williams; E M Goodall; P J Cowen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychopharmacology Volume: 116 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-03-23 Completed Date: 1995-03-23 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 120-2 Citation Subset: IM |
Affiliation:
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Psychopharmacology Research Unit, Littlemore Hospital, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Depression, Chemical Double-Blind Method Eating / drug effects* Female Humans Hunger / drug effects Piperazines / adverse effects, pharmacology* Serotonin Agonists / adverse effects, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Serotonin Agonists; 6640-24-0/1-(3-chlorophenyl)piperazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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