Document Detail

The lymphocyte transformation test with sulphadiminidum and with prealbumin-sulphadiminidum complex in patients with drug allergy.
MedLine Citation:
PMID:  8182216     Owner:  NLM     Status:  MEDLINE    
Earlier results (the absence or a decreased level of prealbumin [PA] in the serum, a higher proportion of PA-bearing lymphocytes as antigen-binding cells, and the presence of PA in the eluate of lymphocytes in patients with drug allergy) permitted the conclusion that, besides its other relevant functions, PA may also behave as a hapten carrier protein. The lymphocyte transformation test (LTT) involving measurement of 3H-thymidine uptake was therefore carried out with sulphadiminidum (SA) alone, with the PA-SA complex, and with the albumin-SA complex in patients with proven (3 cases) or suspected (63 cases) sensitivity to SA. In all 3 cases with proven drug allergy to SA and in 5 of the 63 suspect cases, the LTT was positive in response to both the drug alone and to the PA-SA complex (The albumin-SA complex gave positivity in only one case). In 5 of the 63 suspect cases, the LTT was positive only in response to the PA-SA complex. It is suggested that the sensitivity of the LTT could be increased if the test could be run with a complex of a protein (hapten carrier?) and a drug.
S Husz; A S Kenderessy; M Kiss; B Penke; A Dobozy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of dermatology     Volume:  21     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-14     Completed Date:  1994-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  84-6     Citation Subset:  IM    
Department of Dermatology, Szent-Györgyi Albert Medical University, Szeged, Hungary.
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MeSH Terms
Drug Eruptions / immunology*
Lymphocyte Activation / drug effects*
Prealbumin / pharmacology*
Sulfamethazine / pharmacology*
Reg. No./Substance:
0/Prealbumin; 57-68-1/Sulfamethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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