| The lymph node in HIV pathogenesis. | |
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MedLine Citation:
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PMID: 18620868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the earliest days of the AIDS epidemic, clinicians and researchers have recognized the importance of lymphoid tissue both in the clinical manifestations of disease and in its pathogenesis. Generalized lymphadenopathy was one of the earliest harbingers of AIDS in the United States and over the past 27 years an increasing body of evidence has implicated the lymphoid organs as central to the pathogenesis of immune deficiency in chronic HIV-1 infection. In this essay, we will review some of the data that have been accumulated and propose a testable model that may reconcile them. |
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Authors:
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Michael M Lederman; Leonid Margolis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-07-14 |
Journal Detail:
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Title: Seminars in immunology Volume: 20 ISSN: 1044-5323 ISO Abbreviation: Semin. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-11-25 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 187-95 Citation Subset: IM |
Affiliation:
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Center for AIDS Research, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH 44118, USA. MXL6@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals HIV Infections / immunology*, physiopathology* HIV-1 / physiology* Humans Inflammation / pathology, virology Lymph Nodes / immunology, pathology*, virology* Simian Acquired Immunodeficiency Syndrome / immunology, virology T-Lymphocytes / immunology*, virology Virus Replication / immunology |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI076174-01A1/AI/NIAID NIH HHS; P01 AI076174-01A18498/AI/NIAID NIH HHS; P30 AI036219-14S1/AI/NIAID NIH HHS; U01 AI025879-170004/AI/NIAID NIH HHS; U01 AI025879-179001/AI/NIAID NIH HHS; U01 AI025879-17S4/AI/NIAID NIH HHS; U01 AI069501-02/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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