Document Detail


The luteal phase of nonsupplemented cycles after ovarian superovulation with human menopausal gonadotropin and the gonadotropin-releasing hormone antagonist Cetrorelix.
MedLine Citation:
PMID:  9696235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the luteal phase of six patients undergoing controlled ovarian hyperstimulation (COH) with hMG and a new GnRH antagonist, Cetrorelix, without receiving luteal phase supplementation.
DESIGN: Phase II study involving the first six patients who did not receive luteal phase support.
SETTING: Tertiary referral center.
PATIENT(S): Six healthy women undergoing COH for assisted reproductive techniques.
INTERVENTION(S): Oocyte retrieval was performed 36 hours after hCG administration, followed by embryo transfer 2 days later. No luteal phase supplementation was given.
MAIN OUTCOME MEASURE(S): Serum E2, progesterone, LH, and FSH concentrations were measured.
RESULT(S): The length of the luteal phase was < or =12 days in three of the six patients. One of the patients in whom the luteal phase was >12 days had a low serum progesterone concentration (2.9 ng/mL) on day 10. Serum LH concentrations decreased after the preovulatory hCG injection in all patients. However, a progressive increase in LH was observed after day 7, reaching normal values.
CONCLUSION(S): Corpus luteum function seems to be impaired in cycles that are stimulated with hMG and the GnRH antagonist Cetrorelix.
Authors:
C Albano; G Grimbizis; J Smitz; H Riethmüller-Winzen; T Reissmann; A Van Steirteghem; P Devroey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-9     Citation Subset:  IM    
Affiliation:
Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Belgium. LRIAAOC@AZ.VUB.AC.BE
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MeSH Terms
Descriptor/Qualifier:
Adult
Estradiol / blood
Female
Follicle Stimulating Hormone / blood
Gonadotropin-Releasing Hormone / analogs & derivatives*,  therapeutic use
Hormone Antagonists / therapeutic use*
Humans
Luteal Phase / drug effects*
Luteinizing Hormone / blood
Menotropins / therapeutic use*
Progesterone / blood
Receptors, LHRH / antagonists & inhibitors*
Superovulation*
Chemical
Reg. No./Substance:
0/Hormone Antagonists; 0/Receptors, LHRH; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; OON1HFZ4BA/cetrorelix

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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