| Is lung transplantation survival better in infants? Analysis of over 80 infants. | |
| | |
MedLine Citation:
|
PMID: 23164533 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: There have been >1,600 pediatric lung transplantations (LTx) performed worldwide with a trend toward improved outcomes over the last 25 years. The majority of these LTxs have been in older children and adolescents. Less than 4 infant (defined as≤12 months of age) LTxs per year have been performed over the past 20 years, mostly in the USA. However, infant LTx outcomes have not been well documented in a multi-institutional longitudinal fashion. METHODS: The United Network of Organ Sharing database was queried from October 1987 to July 2011. Of the 1,003 pediatric LTxs reported, 84 (8%) were infants. All combined transplantations were excluded. RESULTS: Eighty-one infants received 84 LTxs, of which 95% had a bilateral LTx. Median age and weight at LTx was 4 months (range 0 to 11 months) and 5.3 kg (2.7 to 11.8 kg), respectively. Median ischemic time was 5.2 hours (2.0 to 10.8 hours). Overall Kaplan-Meier graft survival was similar for infants compared with other pediatric age group (OPA: >1 to 18 years) LTx recipients (half-life 4.0 years vs 3.4 years, p = 0.7). Conditional 1-year graft survival for infants was significantly higher than OPA (half-life 7.4 years vs 5.0 years, p = 0.024). Early (1987 to 2000, n = 46) and late (2001 to 2011, n = 38) era graft survival was not significantly different. Graft survival in pre-LTx ventilated infants was significantly better than pre-LTx ventilated OPA (half-life 6.1 years vs 0.9 year, p = 0.004) and was not statistically different from pre-LTx infants not on ventilatory support (half-life 6.1 years vs 2.2 years, p = 0.152). Cox regression of 5 variables (weight, donor arterial PO(2), pre-Tx ventilator, organ ischemic time, center experience) showed that survival was associated with increased center experience (p = 0.03). CONCLUSION: Infants undergoing LTx have outcomes similar to those of all other pediatric LTx patients. |
| | |
Authors:
|
Muhammad S Khan; Jeffrey S Heinle; Andres X Samayoa; Iki Adachi; Marc G Schecter; George B Mallory; David L S Morales |
Related Documents
:
|
18060943 - Maternal corticosteroid use and orofacial clefts. 17090173 - Palatal size and shape in 6-year olds affected by hypohidrotic ectodermal dysplasia. 15511843 - Outcome of twin pregnancies in maiduguri, nigeria. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-16 |
Journal Detail:
|
Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: - ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Michael E. DeBakey Department of Surgery, Baylor College of Medicine; Division of Congenital Heart Surgery, Texas Children's Hospital. Electronic address: mshoaibkhan@hotmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of monovalent and divalent cations on the stability of silver nanoparticles formed from ...
Next Document: Patients with low compared with high body mass index gain more weight after implantation of a contin...