Document Detail

The lowest surviving birth weight reported in a systemic lupus erythematosus patient: a review of the literature.
MedLine Citation:
PMID:  17283586     Owner:  NLM     Status:  MEDLINE    
The success rates for pregnancies in women with systemic lupus erythematosus (SLE) have improved over the years: however, pregnancy for women with active, serious, organ-threatening lupus continues to be a challenge. Preeclampsia and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome may complicate pregnancy especially in the setting of advanced maternal age, underlying SLE and chronic renal disease. We report the pregnancy course and outcome for a 35-year old woman with active lupus nephritis at the time of conception who developed severe preeclampsia and HELLP syndrome. The infant was delivered at 26-5/7 weeks gestation, which, associated with intrauterine growth retardation, led to a birth weight of only 470 g. We have reviewed the relevant literature for similar cases of prematurity, very low birth weight, and preeclampsia in the setting of underlying lupus in Medline between 1986 and 2006. This report represents the lowest birth weight pregnancy survival in a lupus patient and the first case of a survival in the second trimester with preeclampsia and HELLP syndrome.
J Spiegel; M L Ishimori; D J Wallace; M H Weisman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  16     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-5     Citation Subset:  IM    
Division of Rheumatology, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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MeSH Terms
Anemia, Hemolytic
Birth Weight
Cesarean Section
Fetal Distress / surgery
Fetal Growth Retardation / etiology*
Gestational Age
Infant, Newborn
Infant, Very Low Birth Weight*
Lupus Erythematosus, Systemic*
Lupus Nephritis
Maternal Age
Placenta / blood supply
Placental Insufficiency / etiology*
Pregnancy Complications*
Pregnancy Complications, Hematologic
Pregnancy, High-Risk

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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