Document Detail


The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives.
MedLine Citation:
PMID:  3967403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intra-arterial blood pressure recordings were studied in 10 ambulant subjects with essential hypertension to evaluate the effect of a single daily dose of acebutolol. Blood pressures and heart rates, measured on a beat-to-beat basis were averaged over every hour, for the daytime, night-time, and for the total 24 hours. Acebutolol significantly lowered the average daytime systolic pressure (160 to 142 mmHg, p = less than 0.01), diastolic pressure (78 to 66 mmHg, p = less than 0.01), and the heart rate (92 to 77 beats/min, p = less than 0.001). Significantly lower pressures were demonstrated up to 11 hours after the last dose of acebutolol. The effect on heart rate lasted up to 13 hours. The observed lowering of pressures and heart rate during the remaining 11 hours did not reach statistical significance.
Authors:
S K Mehta; A D Goldberg; J T Walsh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical cardiology     Volume:  8     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-20     Completed Date:  1985-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acebutolol / administration & dosage*,  therapeutic use
Adult
Blood Pressure / drug effects*
Circadian Rhythm*
Female
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Time Factors
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
HL-22032/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
37517-30-9/Acebutolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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