| The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives. | |
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MedLine Citation:
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PMID: 3967403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intra-arterial blood pressure recordings were studied in 10 ambulant subjects with essential hypertension to evaluate the effect of a single daily dose of acebutolol. Blood pressures and heart rates, measured on a beat-to-beat basis were averaged over every hour, for the daytime, night-time, and for the total 24 hours. Acebutolol significantly lowered the average daytime systolic pressure (160 to 142 mmHg, p = less than 0.01), diastolic pressure (78 to 66 mmHg, p = less than 0.01), and the heart rate (92 to 77 beats/min, p = less than 0.001). Significantly lower pressures were demonstrated up to 11 hours after the last dose of acebutolol. The effect on heart rate lasted up to 13 hours. The observed lowering of pressures and heart rate during the remaining 11 hours did not reach statistical significance. |
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Authors:
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S K Mehta; A D Goldberg; J T Walsh |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical cardiology Volume: 8 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-03-20 Completed Date: 1985-03-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 34-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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administration & dosage*,
therapeutic use Adult Blood Pressure / drug effects* Circadian Rhythm* Female Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Time Factors Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-22032/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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37517-30-9/Acebutolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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