| A lower solubility recommends the use of desflurane more than isoflurane, halothane, and enflurane under low-flow conditions. | |
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MedLine Citation:
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PMID: 7772358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To determine whether the lower solubility of desflurane, over that of isoflurane, enflurane, and halothane, favors its use in low-flow anesthesia. DESIGN: Prospective clinical study. SETTING: Technical University of Munich. PATIENTS: 40 elderly (> or = 65 yrs), ASA physical status II and III surgical patients. INTERVENTIONS: All patients were anesthetized and received delivered concentrations (FD) of 4% desflurane, 1.5% isoflurane, 1.8% enflurane, or 0.9% halothane (n = 10 patients for each anesthetic) in a fresh gas inflow of 3 L/min (high-flow), until end-tidal target concentrations (FA) of 2% desflurane, 0.5% isoflurane, 0.6% enflurane, and 0.3% halothane were obtained. After 30 minutes, the inflow was decreased to 1 L/min (low-flow), and the FD and the inspired concentration (FI) were adjusted to maintain the target concentration. MEASUREMENTS AND MAIN RESULTS: The concentrations of the halogenated anesthetics, as well as nitrous oxide, oxygen (O2), and carbon dioxide, were measured in delivered gas at the common gas outlet and at the endotracheal tube connector. Transcutaneous O2 saturation, noninvasive blood pressure, and heart rate were also measured. During the first 30 minutes of high-flow administration, the target concentration was attained sooner with desflurane than with isoflurane, enflurane, or halothane (median levels: 4 min vs. 6 min, 8 min, or 10 min; p < 0.01). After the reduction of inflow to 1 L/min, FD had to be materially increased to maintain F1 and FA for the more soluble anesthetics, but not for desflurane. CONCLUSIONS: At low flows, FD provides a reasonable surrogate of F1 and FA for desflurane, but not for isoflurane, enflurane, or halothane. The rapid and predictable titrability of desflurane favors its safe use in low-flow technique. |
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Authors:
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S Hargasser; R Hipp; B Breinbauer; L Mielke; E Entholzner; M Rust |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical anesthesia Volume: 7 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-07-13 Completed Date: 1995-07-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 49-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthesia, Inhalation / methods* Anesthetics, Inhalation / administration & dosage, analysis, chemistry* Carbon Dioxide / analysis Enflurane / administration & dosage, analysis, chemistry* Female Halothane / administration & dosage, analysis, chemistry* Humans Isoflurane / administration & dosage, analogs & derivatives*, analysis, chemistry* Male Nitrous Oxide / analysis Oxygen / analysis Prospective Studies Rheology Solubility Tidal Volume Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane; 57041-67-5/desflurane; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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J Clin Anesth. 1996 Mar;8(2):169-71
[PMID:
8695103
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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