Document Detail


A low-sodium solution for gastrointestinal lavage.
MedLine Citation:
PMID:  2293568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Golytely is a sodium sulfate-based solution used for lavage cleansing of the colon. Although most patients and physicians prefer Golytely lavage over other methods of bowel cleansing, its highly salty taste is a drawback. This report describes the development of a modified lavage solution that has a barely perceptible salty taste. This solution was developed by removing sodium sulfate, increasing the concentration of polyethylene glycol, and making minor adjustments in the concentration of other salts. Golytely, reduced sodium sulfate Golytely (Golytely-RSS), and a balanced electrolyte solution were infused into the stomachs of normal subjects. After steady-state lavage conditions were established, the rates of fluid and electrolyte absorption were measured. Average fluid absorption rate was 791 ml/h with the balanced electrolyte solution, compared with only 63 and 45 ml/h with Golytely and Golytely-RSS, respectively. Golytely-RSS was studied at 3 infusion rates, from 0.9-1.8 L/h, and the time and volume of solution required for colon cleansing was determined; the lower infusion rate (0.9 L/h) took longer but required less solution to cleanse the colon. In conclusion, Golytely-RSS has the essential feature of Golytely; i.e., lavage is associated with negligible salt and water absorption. The less-salty taste of Golytely-RSS may make it less difficult to drink and thereby enhance patient compliance; the total volume of solution required for cleansing is less when the solution is ingested at 0.9 L/h than when the ingestion rate is 1.8 L/h.
Authors:
J S Fordtran; C A Santa Ana; Cleveland MvB
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  98     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-01-16     Completed Date:  1990-01-16     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
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MeSH Terms
Descriptor/Qualifier:
Colon
Electrolytes / diagnostic use*
Humans
Polyethylene Glycols / diagnostic use*
Solutions
Sulfates / administration & dosage
Taste
Therapeutic Irrigation
Water-Electrolyte Balance / drug effects
Grant Support
ID/Acronym/Agency:
1-ROI-AM37172-03/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Electrolytes; 0/Golytely; 0/Polyethylene Glycols; 0/Solutions; 0/Sulfates; 0YPR65R21J/sodium sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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