Document Detail

A low serum sICAM-1 level may assist in the exclusion of neonatal infection.
MedLine Citation:
PMID:  11844879     Owner:  NLM     Status:  MEDLINE    
Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in 46 samples from 46 infants undergoing intensive care were studied. Residual serum remaining after routine electrolyte analysis was utilised. sICAM-1 levels were determined by ELISA. Blind retrospective chart review was employed to determine whether infants were infected. Serum levels were significantly elevated in infants with proven and probable infection, compared with non-infected infants (p < 0.001). sICAM-1 levels in serum were comparable to levels previously established in plasma samples. The results suggest that serum sICAM-1 measurement is a simple and robust test that differentiates infected from non-infected infants and that a low level of serum sICAM-1 may particularly assist in the exclusion of infection.
David Edgar; Vanessa Gabriel; Adam Craig; Darren Wheeler; Moira Thomas; Judith Grant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  81     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2002  
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Regional Immunology Service, Royal Hospitals Trust, Belfast, UK.
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MeSH Terms
Bacterial Infections / blood*,  diagnosis
Enzyme-Linked Immunosorbent Assay
Infant, Newborn
Infant, Premature / blood*
Intercellular Adhesion Molecule-1 / blood*,  diagnostic use
Retrospective Studies
Reg. No./Substance:
126547-89-5/Intercellular Adhesion Molecule-1

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