Document Detail

A low-order model for left ventricle dynamics throughout the cardiac cycle.
MedLine Citation:
PMID:  22013009     Owner:  NLM     Status:  Publisher    
A theoretical model is used to simulate the dynamics of the left ventricle (LV) through all phases of the cardiac cycle, including interactions between myocardial contractility and ventricular pressure generation and effects of preload and afterload. The ventricle is represented as a cylinder containing helical muscle fibres with non-linear passive and active material properties, embedded in a uniform viscoelastic matrix. The dynamics of the ventricle are represented by a system of differential algebraic equations, whose numerical solution yields pressure-volume loops over successive cardiac cycles. Predicted time-dependent torsional, circumferential and longitudinal strains in the LV are consistent with experimental observations. The model is used to examine the effects of changes in underlying properties of the heart, including myocardial contractility, fibre orientation, passive stiffness, atrial pressure and peripheral resistance, on observable parameters such as stroke work, ejection fraction and end-systolic pressure-volume relationship. Stroke work is shown to be linearly dependent on end-diastolic volume but also to depend on afterload. Diastolic suction and its effect on filling are demonstrated. In this modelling approach, the dynamics of the heart are represented using a low-order dynamical system, and simulations can be carried out much faster than real time. Such a model could potentially be used to deduce patient-specific parameters of ventricular performance on-line from clinically available measurements.
Michael J Moulton; Timothy W Secomb
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  Mathematical medicine and biology : a journal of the IMA     Volume:  -     ISSN:  1477-8602     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182345     Medline TA:  Math Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery, Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Suite #4402, Tucson, AZ 85724, USA.
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