Document Detail

The low number of red blood cells is an important risk factor for all-cause mortality in the general population.
MedLine Citation:
PMID:  22729150     Owner:  NLM     Status:  In-Data-Review    
Patients with advanced chronic kidney disease (CKD) show decreased hemoglobin levels. We aimed to verify the changes of red blood cell (RBC) number according to glomerular filtration rate (GFR) levels and its influence on the clinical outcome. With the data from routine health checkups of 114,496 adults, we grouped the subjects according to quartile levels of RBC number in each gender. Mortality data were from the National Statistical Office. RBC number was increased with decreasing GFR and/or the presence of a component of metabolic syndrome (MS) in subjects with GFR ≥ 50 ml/min/1.73 m<sup>2</sup>. The estimated mean RBC number of subjects with GFR 89-50 ml/min/1.73 m<sup>2</sup> was higher compared to those with GFR ≥ 100 ml/min/1.73 m<sup>2</sup> by ANCOVA. In men, the death rate was the highest in the 1<sup>st</sup> quartile group (1Q) of RBC number (1.22%), followed by the 2<sup>nd</sup> quartile group (2Q, 0.42%), the 3<sup>rd</sup> quartile group (3Q, 0.39%), and the 4<sup>th</sup> quartile group (4Q, 0.29%) (p < 0.001). The hazard ratio (HR) of death in 2Q, 3Q and 4Q was 0.446, 0.580, and 0.440, respectively, compared to 1Q (p < 0.001). Among men in 1Q group, subjects with hemoglobin < 14.0 g/dL showed higher mortality rate than those with hemoglobin 14.0-14.9 g/dL or ≥ 15.0 g/dL (2.3% : 0.8% : 1.1%, respectively, p < 0.001). In conclusion, the RBC number was increased according to declines of GFR in the range of GFR ≥ 50 ml/min/1.73 m<sup>2</sup> and was an important risk factor for mortality.
Yong Chul Kim; Ho Suk Koo; Shin-Young Ahn; Se Won Oh; Sejoong Kim; Ki Young Na; Dong-Wan Chae; Suhnggwon Kim; Ho Jun Chin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  227     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  149-59     Citation Subset:  IM    
Department of Internal Medicine, Seoul National University Hopsital.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.
Next Document:  Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.