| A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity. | |
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MedLine Citation:
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PMID: 12576519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rodents fed fish oil showed less obesity with a reduction of triglyceride synthesis in liver, relative to other dietary oils, along with a decrease of mature form of sterol regulatory element binding protein-1 (SREBP-1) and activation of peroxisome proliferator-activated receptor alpha (PPARalpha). Decrease of mature SREBP-1 protein by fish oil feeding was due to either inhibition of SREBP-1 proteolytic cascade or to decrease of its mRNA. To clarify its mechanism and relation to antiobesity effect, mice were fed fish oil in a range from 10 to 60 energy percent (en%). Fish oil feeding decreased body weight and fat mass in a dose-dependent manner, in parallel with PPARalpha activation and a decrease of SREBP-1 mRNA. However, compared with 0 en% fish oil feeding, 10 en% fish oil feeding decreased mature SREBP-1 protein by 50% with concomitant decreases of lipogenic genes, while precursor SREBP-1 protein rather increased by 1.3-fold. These data suggest that physiological doses of fish oil feeding effectively decrease expression of liver lipogenic enzymes by inhibiting SREBP-1 proteolytic cascade, while substantial decrease of SREBP-1 expression is observed in its pharmacological doses, and that activation of PPARalpha rather than SREBP-1 decrease might be related to the antiobesity effect of fish oil feeding. |
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Authors:
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Teruyo Nakatani; Hyoun-Ju Kim; Yasushi Kaburagi; Kazuki Yasuda; Osamu Ezaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-11-16 |
Journal Detail:
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Title: Journal of lipid research Volume: 44 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-10 Completed Date: 2004-02-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 369-79 Citation Subset: IM |
Affiliation:
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Division of Clinical Nutrition, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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genetics Adipose Tissue / physiology Animals Body Weight CCAAT-Enhancer-Binding Proteins / genetics, metabolism* DNA-Binding Proteins / genetics, metabolism* Dietary Fats / administration & dosage, metabolism Fatty Acid Synthetase Complex / genetics Female Fish Oils / administration & dosage*, metabolism Liver / chemistry, cytology, metabolism, physiology* Mice Mice, Inbred C57BL Muscle, Skeletal / physiology Obesity / metabolism* Organ Size RNA, Messenger / metabolism* Receptors, Cytoplasmic and Nuclear / metabolism Stearoyl-CoA Desaturase / genetics Sterol Regulatory Element Binding Protein 1 Subcellular Fractions / chemistry, metabolism Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CCAAT-Enhancer-Binding Proteins; 0/DNA-Binding Proteins; 0/Dietary Fats; 0/Fish Oils; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 6.-/Fatty Acid Synthetase Complex; EC 6.4.1.2/Acetyl-CoA Carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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