| A low-fat diet supplemented with dietary fish oil (Max-EPA) results in improvement of psoriasis and in formation of leukotriene B5. | |
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MedLine Citation:
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PMID: 2563604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have indicated that certain lipoxygenation products of arachidonic acid, particularly leukotriene B4 (LTB4), may be involved in psoriatic pathophysiology. One way of inhibiting the formation of LTB4 is to replace arachidonic acid in phospholipids with eicosapentaenoic acid. Eicosapentaenoic acid is converted into LTB5, which has a lower biologic activity than LTB4. In the present study psoriatic patients were put on a low-fat diet supplemented with dietary fish oil (Max-EPA 30 ml daily), a source of eicosapentaenoic acid, for 4 months. Twenty-six out of 30 patients with psoriasis vulgaris completed the study. Moderate or excellent improvement was observed in 58% of the patients, while mild improvement or no change was observed in 19% and 23%, respectively. The capacity of peripheral blood neutrophils to synthesize LTB4 and LTB5 in vitro was determined after stimulation with A23187. Before the study, negligible amounts of LTB5 were formed. After 1 month the average of LTB5/LTB4 ratio was 0.42. No further increase of the LTB5/LTB4 ratio was found. There existed no relationship between the clinical response and the LTB5/LTB4 ratio. The results of the present study suggest that dietary fish oil supplementation may be used in the therapy in psoriasis. However, studies defining the dose and the quality of fish oils are imperative. |
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Authors:
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K Kragballe; K Fogh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 69 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-03-17 Completed Date: 1989-03-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Dietary Fats / administration & dosage* Docosahexaenoic Acids* Drug Combinations Eicosapentaenoic Acid / analogs & derivatives*, biosynthesis Fatty Acids, Unsaturated / administration & dosage* Female Fish Oils / administration & dosage Humans Leukotriene B4 / biosynthesis* Male Middle Aged Neutrophils / metabolism Psoriasis / diet therapy*, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Drug Combinations; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Maxepa; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 71160-24-2/Leukotriene B4; 80445-66-5/leukotriene B5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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