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A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.
MedLine Citation:
PMID:  25023988     Owner:  NLM     Status:  Publisher    
We recently demonstrated that both murine and human carcinomas grow significantly slower in mice on low carbohydrate (CHO), high protein diets than on isocaloric Western diets and that a further reduction in tumor growth rates occur when the low CHO diets are combined with the COX-2 inhibitor, celecoxib. Following up on these studies we asked herein what effect low CHO, high protein diets, with or without celecoxib, might have on tumor metastasis. In the highly metastatic 4T1 mouse mammary tumor model, a 15% CHO, high protein diet supplemented with celecoxib (1g/kg chow) markedly reduced lung metastases. Moreover, in longer term studies using male TRAMP mice, which are predisposed to metastatic prostate cancer, the 15% CHO diet, with and without celecoxib (0.3g/kg chow), gave the lowest incidence of metastases, but a more moderate 25% CHO diet containing celecoxib led to the best survival. Metabolic studies with 4T1 tumors suggested that the low CHO, high protein diets may be forcing tumors to become dependent on amino acid catabolism for survival/growth. Taken together, our results suggest that a combination of a low CHO, high protein diet with celecoxib substantially reduces metastasis.
Victor W Ho; Melisa J Hamilton; Ngoc-Ha Thi Dang; Brian E Hsu; Hans H Adomat; Emma S Guns; Aalim Weljie; Ismael Samudio; Kevin L Bennewith; Gerald Krystal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-14
Journal Detail:
Title:  Carcinogenesis     Volume:  -     ISSN:  1460-2180     ISO Abbreviation:  Carcinogenesis     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email:
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