Document Detail


The love of a lifetime: 5-HT in the cardiovascular system.
MedLine Citation:
PMID:  18753260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serotonin [5-hydroxytryptamine (5-HT)] is an amine made from the essential amino acid tryptophan. 5-HT serves numerous functions in the body, including mood, satiety, and gastrointestinal function. Less understood is the role 5-HT plays in the cardiovascular system, although 5-HT receptors have been localized to every important cardiovascular organ and 5-HT-induced changes in physiological function attributed to activation of these receptors. This manuscript relates a few scientific stories that test the idea that 5-HT is important to the control of normal vascular tone, more so in the hypertensive condition. Currently, our laboratory is faced with two different lines of experimentation from which one could draw vastly different conclusions as to the ability of 5-HT to modify endogenous vascular tone and blood pressure. Studies point to 5-HT being important in maintaining high blood pressure, but other studies solidly support the ability of 5-HT to reduce elevated blood pressure. This work underscores that our knowledge of the functions of 5-HT in the cardiovascular system is significantly incomplete. As such, this field is an exciting one in which to be, because there are superb questions to be asked.
Authors:
Stephanie W Watts
Publication Detail:
Type:  Historical Article; Lectures     Date:  2008-08-27
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R252-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg., East Lansing, MI 48824-1317, USA. wattss@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Awards and Prizes
Blood Pressure
Cardiovascular System / metabolism*,  physiopathology
History, 20th Century
History, 21st Century
Humans
Hypertension / history,  metabolism*,  physiopathology
Receptor, Serotonin, 5-HT2B / history,  metabolism
Serotonin / history,  metabolism*
Signal Transduction
Vasoconstriction
Chemical
Reg. No./Substance:
0/Receptor, Serotonin, 5-HT2B; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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