| Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects? | |
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MedLine Citation:
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PMID: 17029304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The loudness dependence of auditory evoked potentials (LDAEP) has been discussed as a non-invasive in vivo marker of central serotonergic function. Evidence for this has been found in animal studies, but studies in humans provide less consistent results. In this study, the relationship between LDAEP and directly modulated central serotonergic activity in healthy subjects was investigated. In a single-blind cross-over design, the LDAEP of female participants (age: 24.0 +/- 2.3 years) was measured under two conditions: (1) infusion of 20 mg citalopram diluted in 250 ml 0.9% saline and (2) infusion of 250 ml 0.9% saline as placebo. LDAEP was measured at five different time points before, during and up to 60 min after drug/placebo administration and dipole source analysis was performed. The increase of the central serotonin activity in response to citalopram was not accompanied by a significant change of the LDAEP compared to the placebo condition. The result underlines that the acceptance of LDAEP as a marker of central serotonergic function still needs further discussion. |
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Authors:
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Idun Uhl; Inge Gorynia; Jürgen Gallinat; Christoph Mulert; Alexander Wutzler; Andreas Heinz; Georg Juckel |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Human psychopharmacology Volume: 21 ISSN: 0885-6222 ISO Abbreviation: Hum Psychopharmacol Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-16 Completed Date: 2007-01-26 Revised Date: 2008-03-06 |
Medline Journal Info:
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Nlm Unique ID: 8702539 Medline TA: Hum Psychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 463-71 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Adult Analysis of Variance Brain / drug effects, physiology Citalopram / pharmacology* Cross-Over Studies Dose-Response Relationship, Radiation Evoked Potentials, Auditory / drug effects* Female Humans Loudness Perception / physiology* Serotonin Uptake Inhibitors / pharmacology* Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Uptake Inhibitors; 59729-33-8/Citalopram |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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