Document Detail


Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women?
MedLine Citation:
PMID:  21795437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Despite the well-known recidivism of obesity, surprisingly little is known about the composition of body weight during weight regain.
OBJECTIVE: The objective of this study was to determine whether the composition of body weight regained after intentional weight loss is similar to the composition of body weight lost.
DESIGN: The design was a follow-up to a randomized controlled trial of weight loss in which body composition was analyzed and compared in 78 postmenopausal women before the intervention, immediately after the intervention, and 6 and 12 mo after the intervention.
RESULTS: All body mass and composition variables were lower immediately after weight loss than at baseline (all P < 0.05). More fat than lean mass was lost with weight loss, which resulted in body-composition changes favoring a lower percentage of body fat and a higher lean-to-fat mass ratio (P < 0.001). Considerable interindividual variability in weight regain was noted (CV = 1.07). In women who regained ≥2 kg body weight, a decreasing trend in the lean-to-fat mass ratio was observed, which indicated greater fat mass accretion than lean mass accretion (P < 0.001). Specifically, for every 1 kg fat lost during the weight-loss intervention, 0.26 kg lean tissue was lost; for every 1 kg fat regained over the following year, only 0.12 kg lean tissue was regained.
CONCLUSIONS: Although not all postmenopausal women who intentionally lose weight will regain it within 1 y, the data suggest that fat mass is regained to a greater degree than is lean mass in those who do experience some weight regain. The health ramifications of our findings remain to be seen.
Authors:
Kristen M Beavers; Mary F Lyles; Cralen C Davis; Xuewen Wang; Daniel P Beavers; Barbara J Nicklas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-07-27
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  94     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-10-31     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  767-74     Citation Subset:  AIM; IM    
Affiliation:
Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. kbeavers@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Aged
Body Composition*
Body Fluid Compartments / metabolism
Female
Follow-Up Studies
Humans
Middle Aged
Muscle, Skeletal / metabolism*
Obesity / metabolism,  physiopathology*
Postmenopause
Weight Gain / physiology*
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
M01-RR07122/RR/NCRR NIH HHS; P30 AG028740/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; R01 AG020583/AG/NIA NIH HHS; R01 HL093713/HL/NHLBI NIH HHS; R01-AG/DK20583/AG/NIA NIH HHS
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