| Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women? | |
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MedLine Citation:
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PMID: 21795437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite the well-known recidivism of obesity, surprisingly little is known about the composition of body weight during weight regain. OBJECTIVE: The objective of this study was to determine whether the composition of body weight regained after intentional weight loss is similar to the composition of body weight lost. DESIGN: The design was a follow-up to a randomized controlled trial of weight loss in which body composition was analyzed and compared in 78 postmenopausal women before the intervention, immediately after the intervention, and 6 and 12 mo after the intervention. RESULTS: All body mass and composition variables were lower immediately after weight loss than at baseline (all P < 0.05). More fat than lean mass was lost with weight loss, which resulted in body-composition changes favoring a lower percentage of body fat and a higher lean-to-fat mass ratio (P < 0.001). Considerable interindividual variability in weight regain was noted (CV = 1.07). In women who regained ≥2 kg body weight, a decreasing trend in the lean-to-fat mass ratio was observed, which indicated greater fat mass accretion than lean mass accretion (P < 0.001). Specifically, for every 1 kg fat lost during the weight-loss intervention, 0.26 kg lean tissue was lost; for every 1 kg fat regained over the following year, only 0.12 kg lean tissue was regained. CONCLUSIONS: Although not all postmenopausal women who intentionally lose weight will regain it within 1 y, the data suggest that fat mass is regained to a greater degree than is lean mass in those who do experience some weight regain. The health ramifications of our findings remain to be seen. |
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Authors:
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Kristen M Beavers; Mary F Lyles; Cralen C Davis; Xuewen Wang; Daniel P Beavers; Barbara J Nicklas |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2011-07-27 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 94 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-22 Completed Date: 2011-10-31 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 767-74 Citation Subset: AIM; IM |
Affiliation:
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Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. kbeavers@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Aged Body Composition* Body Fluid Compartments / metabolism Female Follow-Up Studies Humans Middle Aged Muscle, Skeletal / metabolism* Obesity / metabolism, physiopathology* Postmenopause Weight Gain / physiology* Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR07122/RR/NCRR NIH HHS; P30 AG028740/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; R01 AG020583/AG/NIA NIH HHS; R01 HL093713/HL/NHLBI NIH HHS; R01-AG/DK20583/AG/NIA NIH HHS |
| Comments/Corrections | |
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