Document Detail


The loss of hypoxic ventilatory responses following resuscitation after cardiac arrest in rats is associated with failure of long-term survival.
MedLine Citation:
PMID:  19150439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reperfusion injury induced by cardiac arrest and resuscitation leads to secondary challenges to the brainstem. A 12-minute cardiac arrest results in about a 50% survival rate in resuscitated rats over a 4-day recovery period. We investigated hypoxic ventilatory response (HVR) to mild hypoxia by measuring the minute volume before and during a brief exposure to 10% oxygen before and following cardiac arrest and resuscitation. Our results indicate that after cardiac arrest and resuscitation the baseline spontaneous ventilation was elevated significantly in all rats due to both increased frequency and tidal volume; HVR in the non-survivor group was essentially absent while the brainstem responsiveness to hypoxia is fully maintained in the survivor group. Thus, the HVR was shown in this study to be a reliable indicator of survival vs. non-survival during early days of recovery following cardiac arrest and resuscitation.
Authors:
Kui Xu; Joseph C LaManna
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-01-03
Journal Detail:
Title:  Brain research     Volume:  1258     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-02     Completed Date:  2009-04-21     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / physiopathology*
Disease Models, Animal
Heart Arrest / chemically induced,  mortality*,  physiopathology*
Hypoxia-Ischemia, Brain / physiopathology*
Male
Plethysmography
Potassium Chloride
Rats
Rats, Wistar
Respiration*
Resuscitation / mortality*
Tidal Volume
Tubocurarine
Grant Support
ID/Acronym/Agency:
NS 46074/NS/NINDS NIH HHS; R01 NS038632/NS/NINDS NIH HHS; R01 NS038632-08/NS/NINDS NIH HHS; R01 NS038632-09/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
660YQ98I10/Potassium Chloride; W9YXS298BM/Tubocurarine
Comments/Corrections

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