| The loss of hypoxic ventilatory responses following resuscitation after cardiac arrest in rats is associated with failure of long-term survival. | |
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MedLine Citation:
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PMID: 19150439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reperfusion injury induced by cardiac arrest and resuscitation leads to secondary challenges to the brainstem. A 12-minute cardiac arrest results in about a 50% survival rate in resuscitated rats over a 4-day recovery period. We investigated hypoxic ventilatory response (HVR) to mild hypoxia by measuring the minute volume before and during a brief exposure to 10% oxygen before and following cardiac arrest and resuscitation. Our results indicate that after cardiac arrest and resuscitation the baseline spontaneous ventilation was elevated significantly in all rats due to both increased frequency and tidal volume; HVR in the non-survivor group was essentially absent while the brainstem responsiveness to hypoxia is fully maintained in the survivor group. Thus, the HVR was shown in this study to be a reliable indicator of survival vs. non-survival during early days of recovery following cardiac arrest and resuscitation. |
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Authors:
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Kui Xu; Joseph C LaManna |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-01-03 |
Journal Detail:
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Title: Brain research Volume: 1258 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-02 Completed Date: 2009-04-21 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Stem / physiopathology* Disease Models, Animal Heart Arrest / chemically induced, mortality*, physiopathology* Hypoxia-Ischemia, Brain / physiopathology* Male Plethysmography Potassium Chloride Rats Rats, Wistar Respiration* Resuscitation / mortality* Tidal Volume Tubocurarine |
| Grant Support | |
ID/Acronym/Agency:
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NS 46074/NS/NINDS NIH HHS; R01 NS038632-08/NS/NINDS NIH HHS; R01 NS038632-09/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-95-4/Tubocurarine; 7447-40-7/Potassium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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