Document Detail

The longitudinal variation in uterine artery blood flow pattern in relation to birth weight.
MedLine Citation:
PMID:  15051571     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between the timing of disappearance of high-resistance uterine artery waveforms between the first and second trimester of pregnancy and birth weight. METHODS: Uterine artery Doppler recordings were obtained in a cohort of singleton pregnancies at 11-14 weeks of gestation and subsequently at 18-23 weeks. At each examination, the presence or absence of an early diastolic notch was recorded for each side. An abnormal pattern of blood flow was defined as the presence of bilateral notches. Cases complicated by preeclampsia or preterm delivery were excluded. RESULTS: Four hundred eleven pregnancies showed absent or unilateral uterine artery notches at the 11-14-week scan (group 1). All these cases maintained a low-resistance uterine blood flow pattern at the second-trimester scan. Of the 251 pregnancies with bilateral notches at the 11-14-week scan, 222 subsequently displayed a low-resistance blood flow at 18-23 weeks (group 2) whereas only 29 maintained bilateral notches (group 3). The mean birth weight was higher in group 1 (3452 g) than in groups 2 (3310 g) and 3 (3224 g). This difference was confirmed after adjusting for confounding variables. Small-for-gestational-age fetuses were more common in groups 2 (14.9%) and 3 (14%) compared with group 1 (6.8%, P <.001). During the study period, severe preterm preeclampsia was observed in 6 cases only. CONCLUSION: The longitudinal variation in uterine artery blood flow pattern has a statistically significant correlation with birth weight, likely reflecting the timing and degree of trophoblastic invasion of the maternal vessels. LEVEL OF EVIDENCE: II-2
Federico Prefumo; Melih Güven; Ramesh Ganapathy; Baskaran Thilaganathan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  103     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-05-12     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-8     Citation Subset:  AIM; IM    
Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London, United Kingdom.
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MeSH Terms
Birth Weight*
Infant, Newborn
Longitudinal Studies
Placental Circulation / physiology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Uterus / blood supply*,  physiopathology*,  ultrasonography
Vascular Resistance / physiology*

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