Document Detail


A longitudinal study of red cell enzymes in infants of low birth weight.
MedLine Citation:
PMID:  1179794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A longitudinal study of red cell enzyme activity in newborn infants of low birth weight has been conducted over the first 2 months of life. The enzymes investigated are acetylcholinesterase (EC 3.1.3.7), an integral part of the red cell membrane and subnormal in ABO hemolytic disease of the newborn; and glucose-6-phosphate dehydrogenase (EC 1.1.1.49), an intracellularly-located, sex-linked enzyme, implicated in neonatal jaundice and of significance in drug-induced hemolytic anemias. Acetylcholinesterase activity, which is lower in normal full-term infants and in low birth weight infants than in adults, was further diminished during the initial weeks of life of the infants of low birth weight and the higher levels of activity, characteristic of adult red cells, had not appeared by 2 months of age. By contrast, red cell glucose-6-phosphate dehydrogenase activity, which is higher in full-term newborn infants and in infants of low birth weight than in adults, did not diminish as a function of age and the lower adult levels were not discernible by 2 months of life.
Authors:
F Herz; E Kaplan; E S Scheye
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Kinderheilkunde     Volume:  120     ISSN:  0044-2917     ISO Abbreviation:  Z Kinderheilkd     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-28     Completed Date:  1975-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604363     Medline TA:  Z Kinderheilkd     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / blood
Age Factors
Birth Weight*
Cell Membrane
Erythrocytes / enzymology*
Glucosephosphate Dehydrogenase / blood
Humans
Infant, Newborn
Infant, Premature*
Chemical
Reg. No./Substance:
EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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