| A longitudinal study of personality and major depression in a population-based sample of male twins. | |
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MedLine Citation:
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PMID: 17407614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other. METHOD: In a population-based sample of male twins (n=3030), we attempted to predict major depression (MD) from neuroticism (N) and extraversion (E) and vice versa, to evaluate the causal, scar, state, and prodromal hypotheses. In a longitudinal, structural equation twin model, we decomposed the covariation between N and MD into (a) genetic and environmental factors that are common to both traits, as well as specific to each one and (b) direct causal effects of N at time 1 on subsequent MD, as well as between MD and subsequent N. RESULTS: E was negatively correlated with lifetime and one-year prevalence of MD. N predicted the new onset of MD, and was predicted by both current and past MD. It did not predict the time to onset of MD. All of the covariation between N and MD was due to additive genetic and individual-specific environmental factors shared by both traits and a direct causal path between MD and N assessed later. No genetic factors were unique to either trait. CONCLUSIONS: In men, N may be a vulnerability factor for MD but does not cause it directly. However, MD may have a direct causal effect on N. The genetic overlap between N and MD in men may be greater than in women. |
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Authors:
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Ayman H Fanous; Michael C Neale; Steven H Aggen; Kenneth S Kendler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study Date: 2007-04-04 |
Journal Detail:
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Title: Psychological medicine Volume: 37 ISSN: 0033-2917 ISO Abbreviation: Psychol Med Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-10-16 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 1254142 Medline TA: Psychol Med Country: England |
Other Details:
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Languages: eng Pagination: 1163-72 Citation Subset: IM |
Affiliation:
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Washington VA Medical Center, Washington, DC 20422, USA. ayman.fanous@med.va.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Causality Depressive Disorder, Major / diagnosis, epidemiology*, genetics Diseases in Twins / diagnosis, epidemiology*, genetics Extraversion (Psychology) Humans Longitudinal Studies Male Middle Aged Neurotic Disorders / diagnosis, epidemiology, genetics Personality Inventory Phenotype Registries Sex Factors Social Environment Temperament* Virginia |
| Grant Support | |
ID/Acronym/Agency:
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AA-09095/AA/NIAAA NIH HHS; DA-11287/DA/NIDA NIH HHS; IT-32 MH-20030/MH/NIMH NIH HHS; MH-40828/MH/NIMH NIH HHS; MH/AA/DA-49492/AA/NIAAA NIH HHS |
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