Document Detail


A longitudinal study of personality and major depression in a population-based sample of male twins.
MedLine Citation:
PMID:  17407614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other. METHOD: In a population-based sample of male twins (n=3030), we attempted to predict major depression (MD) from neuroticism (N) and extraversion (E) and vice versa, to evaluate the causal, scar, state, and prodromal hypotheses. In a longitudinal, structural equation twin model, we decomposed the covariation between N and MD into (a) genetic and environmental factors that are common to both traits, as well as specific to each one and (b) direct causal effects of N at time 1 on subsequent MD, as well as between MD and subsequent N. RESULTS: E was negatively correlated with lifetime and one-year prevalence of MD. N predicted the new onset of MD, and was predicted by both current and past MD. It did not predict the time to onset of MD. All of the covariation between N and MD was due to additive genetic and individual-specific environmental factors shared by both traits and a direct causal path between MD and N assessed later. No genetic factors were unique to either trait. CONCLUSIONS: In men, N may be a vulnerability factor for MD but does not cause it directly. However, MD may have a direct causal effect on N. The genetic overlap between N and MD in men may be greater than in women.
Authors:
Ayman H Fanous; Michael C Neale; Steven H Aggen; Kenneth S Kendler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2007-04-04
Journal Detail:
Title:  Psychological medicine     Volume:  37     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-16     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1163-72     Citation Subset:  IM    
Affiliation:
Washington VA Medical Center, Washington, DC 20422, USA. ayman.fanous@med.va.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Causality
Depressive Disorder, Major / diagnosis,  epidemiology*,  genetics
Diseases in Twins / diagnosis,  epidemiology*,  genetics
Extraversion (Psychology)
Humans
Longitudinal Studies
Male
Middle Aged
Neurotic Disorders / diagnosis,  epidemiology,  genetics
Personality Inventory
Phenotype
Registries
Sex Factors
Social Environment
Temperament*
Virginia
Grant Support
ID/Acronym/Agency:
AA-09095/AA/NIAAA NIH HHS; DA-11287/DA/NIDA NIH HHS; IT-32 MH-20030/MH/NIMH NIH HHS; MH-40828/MH/NIMH NIH HHS; MH/AA/DA-49492/AA/NIAAA NIH HHS

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