Document Detail

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia.
MedLine Citation:
PMID:  17570643     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have reported that hippocampal volumes correlate with symptom severity in schizophrenia. This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine. METHODS: MRI scans were acquired from patients with chronic schizophrenia (n=10) and healthy volunteers (n=20). At baseline, patients were treated with typical antipsychotics for at least one year, then switched to olanzapine, and rescanned approximately one year later. RESULTS: Olanzapine treatment resulted in no significant change in right or left hippocampal volume. Individual changes in right hippocampal volume correlated significantly with changes in symptoms. CONCLUSIONS: Hippocampal volume change may serve as a marker of symptom change in patients on olanzapine.
William J Panenka; Babak Khorram; Alasdair M Barr; Geoffrey N Smith; Donna J Lang; Lili C Kopala; Robert A Vandorpe; William G Honer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-13
Journal Detail:
Title:  Schizophrenia research     Volume:  94     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-10-11     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  288-92     Citation Subset:  IM    
Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada, V5Z 1L8.
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MeSH Terms
Antipsychotic Agents / pharmacology*,  therapeutic use*
Benzodiazepines / pharmacology,  therapeutic use
Chronic Disease
Diagnostic and Statistical Manual of Mental Disorders
Follow-Up Studies
Hippocampus / anatomy & histology*,  drug effects*
Magnetic Resonance Imaging*
Schizophrenia / diagnosis*,  drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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