| A longitudinal study of the corpus callosum in chronic schizophrenia. | |
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MedLine Citation:
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PMID: 19713080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood. METHODS: We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic schizophrenia patients and 16 healthy comparison subjects. Schizophrenia patients were subdivided into good-outcome (n=23) and poor-outcome (n=26) groups. Baseline-to-follow-up changes in size, shape, position and fractional anisotropy of the corpus callosum, divided into five sagittal sections and five rostro-caudal segments, were assessed. RESULTS: At baseline scan and in comparison to healthy subjects, schizophrenia patients displayed 1) smaller callosal size, 2) lower average anisotropy in all sagittal sections except the midline, and 3) more dorsal average coordinate position. During the four years after the baseline scan, patients with schizophrenia exhibited a more pronounced decline in absolute size of the corpus callosum than healthy comparison subjects. As compared with the good-outcome group, the corpus callosum in poor-outcome patients at baseline was of smaller size and lower average anisotropy, more elongated and posteriorly positioned. During the follow-up interval, poor-outcome patients displayed a more pronounced decline in size but less pronounced decline in anisotropy of the corpus callosum than patients with good outcomes. CONCLUSIONS: Differences in callosal size between schizophrenia patients and healthy subjects seen at baseline continue to widen in the chronic phase of the illness, especially in patients with poor functional outcome. Baseline differences in callosal anisotropy among patients with different outcomes, however, diminish over time. |
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Authors:
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Serge A Mitelman; Yekaterina K Nikiforova; Emily L Canfield; Erin A Hazlett; Adam M Brickman; Lina Shihabuddin; Monte S Buchsbaum |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-26 |
Journal Detail:
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Title: Schizophrenia research Volume: 114 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-12-07 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 144-53 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA. serge.mitelman@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anisotropy Brain Mapping* Chronic Disease Corpus Callosum / pathology* Diffusion Magnetic Resonance Imaging / methods Disease Progression Female Humans Image Processing, Computer-Assisted / methods Longitudinal Studies Magnetic Resonance Imaging / methods Male Middle Aged Schizophrenia / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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MH 077146/MH/NIMH NIH HHS; MH 56489/MH/NIMH NIH HHS; MH 60023/MH/NIMH NIH HHS; P50 MH 66392-01/MH/NIMH NIH HHS; R03 MH077146-02/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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