Document Detail

A longitudinal study of cell-mediated immunity in human pregnancy.
MedLine Citation:
PMID:  7277339     Owner:  NLM     Status:  MEDLINE    
Studies of cell-mediated immunity, comprising delayed hypersensitivity skin testing with four antigens, PHA and antigen-induced lymphocyte transformation and detection of the lymphokine, monocyte chemotactic factor, were undertaken in 14 women during pregnancy and in the post-natal period. Skin test reaction sizes to SKSD, PPD, Candida albicans extract and tetanus toxoid were not significantly different during pregnancy. In vitro lymphocyte transformation induced by PHA, SKSD and Candida albicans was enhanced during pregnancy. Monocyte chemotactic factor production was not significantly different during pregnancy. These in vitro tests were performed in the absence of autologous sera. These studies indicate that cell-mediated immune responses are normal during human pregnancy.
C S Hawes; A S Kemp; W R Jones; J A Need
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  3     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  165-73     Citation Subset:  IM    
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MeSH Terms
Hypersensitivity, Delayed / diagnosis
Immunity, Cellular*
Longitudinal Studies
Lymphocyte Activation
Lymphokines / biosynthesis
Skin Tests
Reg. No./Substance:

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