| A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis. | |
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MedLine Citation:
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PMID: 11176943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine if callosal atrophy and interhemispheric dysfunction can be detected in the early stages of relapsing-remitting multiple sclerosis (MS) and to evaluate their progression in relation to the disability and evolution of lesions seen on magnetic resonance imaging during a 5-year period. METHODS: We compared 30 patients who had clinically definite early-onset replasing-remitting MS and mild disability with control subjects. Regional and segmental callosal size and extent of white matter abnormalities on magnetic resonance imaging, as well as performance on tasks exploring interhemispheric transfer of motor, auditory, and sensory information were assessed. Patients with MS were evaluated at baseline and after 5 years. Physical disability was determined at both times using the Expanded Disability Status Scale score. RESULTS: Patients with MS were seen with significant callosal atrophy and functional impairment of interhemispheric transfer at baseline that worsened during the 5-year study. A significant correlation was found between the magnitude of disability and the severity of morphological and functional callosal involvement at baseline. This association persisted at year 5. Baseline clinical characteristics such as age and prestudy relapse rate were unrelated to callosal size or interhemispheric performance. However, the number of baseline T2-weighted lesions was correlated with callosal involvement and this relation persisted at year 5. CONCLUSION: Patients who had relapsing-remitting MS in the early stages of the disease and mild disability had significant callosal involvement that progressed over time. The relationship between disability, T2-weighted lesions load, and degree of morphological and functional callosal impairment confirm the potential value of using callosal dysfunction as a surrogate marker of disease progression in MS. |
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Authors:
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J Pelletier; L Suchet; T Witjas; M Habib; C R Guttmann; G Salamon; O Lyon-Caen; A A Chérif |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of neurology Volume: 58 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 105-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, CHU Timone, F-13385 Marseilles 5, France. jpelletier@ap-hm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Atrophy / pathology Corpus Callosum / pathology*, physiopathology* Dichotic Listening Tests Disability Evaluation Disease Progression Evoked Potentials, Auditory, Brain Stem / physiology Female Functional Laterality / physiology Humans Longitudinal Studies Magnetic Resonance Imaging Male Multiple Sclerosis, Relapsing-Remitting / diagnosis*, physiopathology* Neuropsychological Tests Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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