| A longitudinal study of the association between dietary factors, serum lipids and bone marrow lesions of the knee. | |
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MedLine Citation:
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PMID: 22257370 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: INTRODUCTION: Bone marrow lesions (BMLs) play an important role in knee osteoarthritis but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids and BMLs. METHODS: A total of 394 older males and females (mean age 63 years, range 52 to 79) were measured at baseline and approximately 2.7 years later. BMLs were determined using T2-weighted fat saturation magnetic resonance imaging (MRI) by measuring the maximum area of the lesion. Nutrient intake (total energy, fat, carbohydrate, protein and sugar) and serum lipids were assessed at baseline. RESULTS: Cross-sectionally, dietary factors and lipids were not significantly associated with BMLs. Energy, carbohydrate and sugar intake (but not fat) were positively associated with a change in BML size (beta = 15.44 to 19.27 mm2 per 1 SD increase, all P < 0.05). High-density lipoprotein (HDL) cholesterol tended to be negatively associated with BML change (beta = -11.66 mm2 per 1 SD increase, P = 0.088). CONCLUSIONS: Energy, carbohydrate and sugar intake may be risk factors for BML development and progression. HDL cholesterol seems protective against BMLs. These results suggest macronutrients and lipids may be important in BML etiology and that dietary modification may alter BML natural history. |
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Authors:
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Dawn Dore; Jonathon de Hoog; Graham Giles; Changhai Ding; Flavia Cicuttini; Graeme Jones |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Arthritis research & therapy Volume: 14 ISSN: 1478-6362 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154438 Medline TA: Arthritis Res Ther Country: - |
Other Details:
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Languages: ENG Pagination: R13 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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